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Godan verb with 'ru' ending, transitive verb
to give up all thoughts of, to abandon, to despair of
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彼女の事が思い切れない。
I can't forget her.
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Godan verb with 'ru' ending, intransitive verb
to make up one's mind, to take a momentous decision
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重病には思い切った療法が必要だ。
Desperate diseases require desperate remedies.
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